Impulsivity and Amplitude of Event-Related Potential P300 in Patient Methadone Maintenance Treatment Program in Bandung

Impulsivity and Amplitude of Event-Related Potential 

P300 in Patient Methadone Maintenance Treatment 

Program in Bandung

Oral Presentation

Presented by 

N.R. Febrianti Santiardi Danasasmita, Shelly Iskandar, 

Teddy Hidayat2, Arifah Nur Istiqomah, Dwi Esti Kusumandari, 

Arjon Turnip

Background: Methadone Maintenance Treatment (MMT) is an official program of the Indonesian government to reduce the adverse impacts of injecting opioid use. Several studies have suggested that MMT exhibit poorer performance in impulsivity. High impulsive demonstrated reduced cognitive performance and it is reflected in their reduced P300 amplitude. Research on P300 in patients with MMT group conducted by Muller states no difference in latency and P300 amplitude between MMT group and control group, whereas Attou study stated that the amplitude of P300 in the smaller in MMT group. While Baldacchino stated impulsivity is impaired in active heroin user groups compared with MMT group. With the presence of different research results, it is expected that this study can compare impulsivity and amplitude of P300 in patients on MMT group, addiction without MMT and healthy subject.

Method: Subject were divided into 3 groups: addictions group without MMT (9 people), MMT group (9 people), and healthy subjects (10 people). Each group erformed impulsivity checks using Barratt Impulsiveness Scale 11, then conducted EEG event-related potential P300. Statistical analysis to assess comparison of P300 measurements and inter-group impulsivity was used ANOVAanalysis. 

Result: There was no significant difference of impulsivity in MMT, addiction group without MMT, and control group. There was no significant difference in amplitude of P300 similar stimuli in frontal targets between MMT groups, addiction group without MMT, and controls. There is no correlation between impulsivity and amplitude of P300 similar stimuli on frontal targets. 

Conclusion: The results of this study do not fit with previous studies on impulsivity and P300 in MMT. These different results indicate that other factors play a role in impulsivity and EEG P300 in drug users and methadone. So further research is needed on impulsivity and EEG P300 on drug users with more specific criteria. 

Keywords: methadone, impulsivity, P300, amplitude 

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